The in vitro activity of iron chelator deferiprone against Candida (Candidozyma) auris in combination with antifungal agents.

ABSTRACT: Candida (Candidozyma) auris is well known for its limited susceptibility to conventional antifungal agents, underscoring the need for novel alternative therapeutic approaches. One such approach, which involves restricting the availability of micronutrients-including iron-is a promising antimicrobial strategy and proven to enhance the efficacy of various antimicrobial agents in vitro. In this study, we evaluated the activity of deferiprone, a clinically approved iron-chelating agent, in combination with echinocandins, amphotericin B and fluconazole against C. auris strains, including three echinocandin-resistant isolates representing the four major clades. Drug-drug interactions were assessed using the chequerboard methodology. Fractional inhibitory concentration index scores ranged from 0.

SUBMITTER: Toth Z 

PROVIDER: S-EPMC12743188 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature