Pharmacotherapy and overdose risk following new opioid use disorder diagnosis among Medicaid beneficiaries.

ABSTRACT: Background: Timely initiation and continuation of medications for opioid use disorder (MOUD) following a new opioid use disorder (OUD) diagnosis reduces overdose risk.Objectives: To examine patient- and community-level factors associated with timely MOUD receipt and the association of these factors and MOUD modality (buprenorphine, methadone, naltrexone) with subsequent overdose.Methods: This cohort study included Medicaid enrollees in 44 states aged 18-64 with a new OUD diagnosis between April 2016 and December 2019. Multivariable Cox Proportional Hazards models assessed time (in days) to MOUD receipt and medically-treated nonfatal overdose stratified by involvement of heroin/synthetic vs. other (primarily prescription) opioids only. Models adjusted for patient, count

SUBMITTER: Treitler P 

PROVIDER: S-EPMC12743245 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature