Multidimensional pH-Temperature Mapping of SABRE-SHEATH ¹³C Hyperpolarization of [1-¹³C]Pyruvate.

ABSTRACT: Hyperpolarized [1-¹³C]pyruvate has emerged as a next-generation molecular probe for in vivo metabolic flux imaging in deep tissue. This molecular contrast agent is now under evaluation in over 50 clinical trials, according to clinicaltrials.gov. Hyperpolarized [1-¹³C]pyruvate is produced through dissolution dynamic nuclear polarization (d-DNP) for clinical research use. This remarkable hyperpolarization technique is regarded as expensive (>$2 M equipment cost) and slow (1 h production). One alternative hyperpolarization technique called Signal Amplification By Reversible Exchange (SABRE) in SHield Enables Alignment Transfer to Heteronuclei (SABRE-SHEATH) has recently garnered substantial attention for production of hyperpolarized [1-¹³C]pyruvate quic

SUBMITTER: Adelabu I 

PROVIDER: S-EPMC12743356 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature