Molecular mechanistic insights into the OX40-OX40L complex from biophysical and computational analyses.

ABSTRACT: OX40 and OX40L belong to the tumor necrosis factor receptor superfamily (TNFRSF) and tumor necrosis factor superfamily (TNFSF), respectively. Protein-protein interactions between OX40 and OX40L facilitate T cell responses, triggering various immunological and pathophysiological events. Excessive activation frequently contributes to the onset of autoimmune and allergic diseases. Therefore, the OX40/OX40L system is considered a promising target for drug discovery. Given that the structure of the OX40-OX40L complex exhibits some unique features compared to other members of these protein super families, it is reasonable to assume that this tandem possesses distinct interaction mechanisms. However, detailed interaction analysis using quantitative parameters such as binding kinetics or thermodyn

SUBMITTER: Nishimuta H 

PROVIDER: S-EPMC12743370 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature