Global variations of IgE cross-reactivity in Cupressus allergy.

ABSTRACT:

Background

Seasonal allergic rhinitis triggered by Cupressaceae species is a significant concern worldwide, particularly in regions such as Japan, China, Spain, and the United States.

Objective

This study investigated specific IgE responses to Cupressaceae species and the potential clinical relevance of cross-reactivity, focusing on Japanese cedar (Cryptomeria japonica [Cry j]), which is a major allergenic species in Japan.

Methods

We analyzed serum samples from 609 patients across 4 countries to measure levels of specific IgE using ImmunoCAP. We assessed IgE reactivity against Cry j extract and other Cupressaceae species, including Arizona cypress and red cedar extracts, to delineate patterns of reactivity.

Results

Levels of specific IgE against Cry j w

SUBMITTER: Sugawara T 

PROVIDER: S-EPMC12743450 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature