Comparative analysis of non-invasive fibrosis markers: Insights from chronic HBV, HBV+HDV, and HCV infections.

ABSTRACT:

Background

Chronic viral hepatitis remains a significant global health burden, with accurate assessment of liver fibrosis being crucial for patient management. This study aimed to evaluate the diagnostic accuracy of non-invasive tests (NITs) for liver fibrosis assessment in patients with chronic hepatitis B (HBV), hepatitis B and D co-infection (HBV + HDV), and hepatitis C (HCV) infections.

Methods

A prospective study was conducted on 78 patients with chronic viral hepatitis (22 HBV, 34 HBV + HDV, 22 HCV). Participants underwent magnetic resonance elastography (MRE), transient elastography (TE), and serum biomarker testing (APRI, FIB-4, PIIINP, COL4). MRE was used as the reference standard for liver fibrosis staging.

Results

Transient elastography demonstrated the hig

SUBMITTER: Khikmatullaeva AS 

PROVIDER: S-EPMC12743508 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature