Impact of patient phenotype on the relationship between accelerometer-derived physical activity and cardiovascular events in atrial fibrillation.

ABSTRACT:

Aims

Atrial fibrillation (AF) is a heterogeneous condition with varying comorbidity profiles, yet current physical activity guidelines do not differentiate between AF phenotypes. We examined the association between objectively measured moderate-to-vigorous physical activity (MVPA) and major adverse cardiovascular events (MACE) across different AF phenotypes.

Methods

In a prospective cohort of 4858 adults with AF (mean age 63, 37 % female) from the UK Biobank, wrist-worn accelerometry quantified MVPA. Hierarchical clustering classified individuals into 'high' and 'low' risk clusters based on comorbidities. Activity patterns were also described by rhythm control treatment status. Cox-proportional hazards models assessed the association between MVPA and MACE across clusters, wh

SUBMITTER: Boidin M 

PROVIDER: S-EPMC12743516 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature