MAIT cell heterogeneity across paired human tissues reveals specialization of distinct regulatory and enhanced effector profiles.

ABSTRACT: Mucosal-associated invariant T (MAIT) cells are unconventional T cells that recognize microbial riboflavin pathway metabolites presented by evolutionarily conserved MR1 molecules. We explored the human MAIT cell compartment across organ donor-matched blood, barrier, and lymphoid tissues. MAIT cell population size was donor dependent with distinct tissue compartmentalization patterns and adaptations: Intestinal CD103⁺ resident MAIT cells presented an immunoregulatory CD39^highCD27^low profile, whereas MAIT cells expressing NCAM1/CD56 dominated in the liver and exhibited enhanced effector capacity with elevated response magnitude and polyfunctionality. Both intestinal CD39^high and hepatic CD56⁺ adaptations accumulated with donor age. CD56<

SUBMITTER: Kammann T 

PROVIDER: S-EPMC12743559 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature