A Comparison of Emotionally Stimulated and Conventionally Collected Tears Using Bottom-Up, Label-Free Quantitative Proteomic Analysis-A Pilot Study.

ABSTRACT: Proteomic analysis of biofluids is central for identifying disease biomarkers. Tears have become popular targets for biomarker discovery and biosensor development, largely because they can be collected noninvasively and are rich sources of biomarkers for ocular and systemic diseases. Although basal and reflex tears have been well characterized, the proteome of psycho-emotionally stimulated tears remains largely unexplored, hindering their applicability in biomarker discovery studies and the advancement of tear-based biosensors. Comprehensive proteomic analysis across different tear types is crucial for identifying novel biomarkers and improving disease diagnosis and monitoring. In this pilot study, tears collected via conventional stimulation techniques ("standard") versus those elicited t

SUBMITTER: Mousseau CB 

PROVIDER: S-EPMC12743588 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature