Proteomic Biomarkers Are Linked to QTc Interval in Patients With Chronic Heart Failure.

ABSTRACT:

Objective

This study investigates the link between circulating proteins and rate-corrected QT (QTc) interval in patients with heart failure with reduced ejection fraction (HFrEF) and their association with cardiovascular outcomes.

Methods and results

We analyzed 197 HFrEF patients from the prospective Serial Biomarker Measurements and New Echocardiographic Techniques in Chronic Heart Failure Patients Result in Tailored Prediction of Prognosis (Bio-SHiFT) study, all in sinus rhythm at baseline. Baseline QTc intervals were calculated and corrected for broad QRS complexes (>120 ms) using Bogossian's formula. Using the Somalogic-SomaScan Assay, 1105 cardiovascular-related proteins were measured in baseline blood samples. Linear regression identified 11 biomarkers significantly a

SUBMITTER: Barry-Loncq de Jong M 

PROVIDER: S-EPMC12743590 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature