Estimation of tissue-water linear stopping power ratio of the proton beam from proton density-weighted MRI.

ABSTRACT:

Background

In MRI-integrated radiotherapy, image registration between magnetic resonance imaging (MRI) and computed tomography (CT) can introduce systematic errors of up to 5 mm. To avoid such errors in proton therapy, one of the prerequisites is the determination of the tissue-water linear stopping power ratio Stissue,water${S}_{\textit{tissue},\ \mathrm{water}}$ from MRI for treatment planning.

Purpose

Stissue,water${S}_{\textit{tissue},\ \mathrm{water}}$ depends on the elemental composition of the medium. Proton density-weighted MRI measures the concentration of hydrogen ( 11H${}_1^1{\mathrm{H}}$ ), which is independent of the magnetic field strength. This study evaluated the potential of proton density-weighted MRI to estimate Stissue,water${S}_{\textit{tissue},\ \mathrm

SUBMITTER: Chakraborty P 

PROVIDER: S-EPMC12743598 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature