Markers for mapping by admixture linkage disequilibrium in African American and Hispanic populations.

ABSTRACT: Population linkage disequilibrium occurs as a consequence of mutation, selection, genetic drift, and population substructure produced by admixture of genetically distinct ethnic populations. African American and Hispanic ethnic groups have a history of significant gene flow among parent groups, which can be of value in affecting genome scans for disease-gene discovery in the case-control and transmission/disequilibrium test designs. Disease-gene discovery using mapping by admixture linkage disequilibrium (MALD) requires a map of polymorphic markers that differentiate between the founding populations, along with differences in disease-gene allele frequencies. We describe markers appropriate for MALD mapping by assessing allele frequencies of 744 short tandem repeats (STRs) in African Americ

SUBMITTER: Smith MW 

PROVIDER: S-EPMC1274377 | biostudies-literature | 2001 Nov

REPOSITORIES: biostudies-literature