Effectiveness of ustekinumab in Crohn's disease across intestinal locations: spotlight on isolated small intestinal involvement.

ABSTRACT:

Background

Small intestinal-predominant Crohn's disease (CD) exhibits distinct therapeutic patterns and is characterized by increased biological use and intestinal resection rates. However, systematic evaluations of the objective response of ustekinumab (UST), particularly related to disease location, are limited.

Objectives

To compare the therapeutic efficacy of UST between small intestinal CD (SICD) and non-small intestinal CD (NSICD).

Design

A prospective observational cohort study.

Methods

Demographic and clinical characteristics were collected at baseline and 52-week follow-up, assessments including endoscopy, imaging, ultrasonography (US), histopathology, fecal calprotectin (FCP), C-reactive protein (CRP), and hemoglobin results. Patients with isolated il

SUBMITTER: Yu Y 

PROVIDER: S-EPMC12743847 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature