Successful dual therapy of aztreonam and ceftazidime-avibactam for multidrug-resistant <i>Stenotrophomonas maltophilia</i> infection in a preterm neonate: A life-saving approach.

ABSTRACT: Stenotrophomonas maltophilia is a multidrug-resistant gram-negative pathogen associated with high morbidity and mortality, especially in immunocompromised patients. Its resistance mechanisms include aminoglycoside-modifying enzymes, qnrB-like quinolone resistance genes, multidrug efflux pumps, and β-lactamases (L1 and L2). With the increasing incidence of S. maltophilia infections, effective treatment strategies are urgently needed to combat its growing resistance. We present the case of a preterm male neonate, born at 30 weeks of gestation, who developed respiratory distress requiring mechanical ventilation. Empiric antibiotics were initiated but failed to prevent clinical deterioration. Respiratory cultures confirmed that multidrug-resistant S. maltophilia is

SUBMITTER: Alghamdi AO 

PROVIDER: S-EPMC12743881 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature