Dose and duration shape the efficacy of vonoprazan versus lansoprazole for erosive esophagitis: insights from meta-regression.

ABSTRACT:

Background

Proton pump inhibitors (PPIs) are the standard treatment for erosive esophagitis (EE), yet 20%-40% of patients show inadequate response. Vonoprazan, a potassium-competitive acid blocker (P-CAB), provides faster and more sustained acid suppression than PPIs.

Objectives

To evaluate the efficacy and safety of vonoprazan compared with lansoprazole in the treatment and maintenance of EE, and to explore dose-response and duration effects using meta-regression analysis.

Design

Systematic review and meta-analysis of randomized controlled trials (RCTs).

Data sources and methods

Electronic databases (PubMed, Embase, Cochrane CENTRAL, ClinicalKey, ProQuest, ScienceDirect, Web of Science, and ClinicalTrials.gov) were searched through March 31, 2025. Eligible RCT

SUBMITTER: Huang PF 

PROVIDER: S-EPMC12743997 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature