RBPMS and RBPMS2 Cooperate to Safeguard Cardiac Splicing.

ABSTRACT:

Background

Mutations in cardiac SFs (splicing factors) cause cardiomyopathy and congenital heart disease, underscoring the critical role of SFs in cardiac development and disease. Cardiac SFs are implicated to cooperatively regulate the splicing of essential cardiac genes, but the functional importance of their collaboration remains unclear. RBPMS (RNA-binding protein with multiple splicing) and RBPMS2 (RNA-binding protein with multiple splicing 2) are SFs involved in heart development and exhibit similar splicing regulatory activities in vitro, but it is unknown whether they cooperate to regulate splicing in vivo.

Methods

Rbpms and Rbpms2 single- or double-cardiomyocyte-specific knockout (KO) mice were generated and analyzed for cardiac phenotypes. RNA sequenc

SUBMITTER: Wu T 

PROVIDER: S-EPMC12744351 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature