Imaging Canine Post-Trabecular Aqueous Outflow Pathways: Effect of Acute Intraocular Pressure Elevation in Normal Eyes.

ABSTRACT:

Purpose

To investigate the relationship between increased intraocular pressure (IOP) and the structure of the post-trabecular aqueous outflow tract of dogs.

Methods

Ex vivo aqueous angiography (AA) and anterior segment optical coherence tomography (OCT) were performed concurrently in 19 normal canine eyes, following cannulation and intracameral infusion of 2.5% fluorescein and/or indocyanine green (ICG) after maintaining eyes at physiologic IOP (10-25 mmHg) for 30 min and/or elevated IOP (55-68 mmHg) for 30 or 120 min. Scleral lumen heights (SLH) of vascular profiles in OCT scans were measured by Image J, and values analyzed in linear regression models. In a subset of 10 eyes, each quadrant was subjectively characterized as being either a high-flow or low-flow region based o

SUBMITTER: Torne O 

PROVIDER: S-EPMC12744534 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature