Epigenetic regulation of NAFLD: A preclinical study.

ABSTRACT: Background & objectives Non-alcoholic fatty liver disease (NAFLD) is considered as the most prevalent chronic metabolic disease, characterised by steatosis, inflammation, and metabolic dysfunctions with impaired functions of liver enzymes. The fat mass and obesity-associated gene (FTO) plays an important role in fat accumulation in hepatocytes. We investigated how FTO regulated the expression of its target genes via m6A modification leading to the pathophysiology of NAFLD. Methods A NAFLD mouse model was developed by feeding C57Bl/6 male mice on high-fat, high-carbohydrate (HFHC) diet supplemented with fructose and sucrose up to 24 wk. Changes in the liver histology were examined in serial sections by microscopy and immunohistochemistry, the serum parameters were monitored by bioanalyser a

SUBMITTER: Giri S 

PROVIDER: S-EPMC12744571 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature