The 'non-conventional' peptidome: A new layer in plant regulatory mechanisms.

ABSTRACT: A substantial but largely unexplored fraction of eukaryotic proteomes is composed of peptides and small proteins (the peptidome). In recent years, short open reading frames (sORFs) capable of encoding functional peptides have been identified within transcripts annotated as non-coding RNAs or in intergenic regions. These sORF-encoded peptides (SEPs) were previously overlooked due to their small size and difficulties in detection, both experimentally and computationally. However, analyses of translating RNAs (ribosome profiling) and proteomics (mass spectrometry) have provided growing evidence for the existence of numerous novel 'non-conventional' peptides in eukaryotic organisms, including plants. In animals, mounting evidence indicates that long non-coding RNAs are an important source of S

SUBMITTER: Alvarez-Urdiola R 

PROVIDER: S-EPMC12744755 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature