Continuous Subcutaneous Insulin Infusion Versus Multiple Daily Injections for Glycemic Management in Pregnant Women With Type 1 Diabetes: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background/objective

To compare glycemic management outcomes between continuous subcutaneous insulin infusion (CSII) and multiple daily injections in pregnancy and assess maternal and neonatal outcomes. There is an ongoing increase in diabetes rates worldwide. The International Diabetes Federation estimated that there were 23.0 million cases of hyperglycemia (19.7%) before and during pregnancy in 2024 worldwide, causing 1.5 million deaths annually. Pregnant women with pregestational type 1 diabetes mellitus (T1DM) struggle with 2-4 times more maternal and fetal complications than pregnant women without diabetes.

Methods

Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we searched PubMed MEDLINE, Cochrane, Scopus, Web of Science, Em

SUBMITTER: Alonso Ramirez AC 

PROVIDER: S-EPMC12744806 | biostudies-literature | 2025 Nov-Dec

REPOSITORIES: biostudies-literature