Shared genetic associations between CHA₂DS₂-VASc score and cardio-embolic stroke: Insights from mendelian randomization based bioinformatics analysis.

ABSTRACT: The CHA₂DS₂-VASc score is a risk assessment score to predict cardio-embolic stroke (CES), suggesting shared genetic susceptibility. This study aimed to explore the shared genetic association of genetically predicted CHA₂DS₂-VASc score and CES using multiple analytic frameworks. We conducted a comprehensive analysis of genetic data from 13 traits of CHA₂DS₂-VASc score and CES using summary statistics from large-scale genome-wide association studies (GWAS). We employed statistical methods such as linkage disequilibrium score regression (LDSC), cross-trait analysis, bidirectional Mendelian randomization, colocalization analysis and gene-based association analysis to explore genetic correlations and identify pleiotropic single n

SUBMITTER: Yuan K 

PROVIDER: S-EPMC12744818 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature