Prairie voles seek social contact with peer companions during immune challenge.

ABSTRACT: Selection for group living has occurred across taxa, despite inherent risk of disease transmission. Behavioral and immune responses to sickness affect social interactions and can be altered by social contexts. However, the majority of research on sickness behavior has focused on species that do not form selective social relationships. Prairie voles (Microtus ochrogaster) form selective social relationships with mates and peers and provide a useful study system to examine effects of sickness on social seeking in established relationships. We used peripheral injections of lipopolysaccharide (LPS) of E. coli to stimulate the innate immune system and verified effects on activity, core temperature, and corticosterone concentrations for 6 h following treatment. We demonstrated that male and fema

SUBMITTER: Young GK 

PROVIDER: S-EPMC12744819 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature