Synergic microRNAs suppress human glioblastoma progression by modulating clinically relevant targets.

ABSTRACT: Glioblastoma (GBM) is a highly aggressive brain tumor characterized by therapy-resistant glioma stem-like cells (GSCs) and extensive infiltration into surrounding brain tissue. MicroRNAs (miRNAs) are pleiotropic post-transcriptional regulators of oncogenic pathways, but their tumor-suppressive function is frequently lost in GBM. This study explores a multimodal therapeutic approach by restoring a combination of miRNAs to exploit their synergistic effects against GBM. Using patient-derived GBM cells cultured under stem cell-permissive conditions, we demonstrate that miRNA restoration reduces tumor growth, limits invasiveness and stemness, and enhances sensitivity to temozolomide (TMZ). In vivo studies in an orthotopic xenograft mouse model of GBM confirm the therapeutic efficacy and

SUBMITTER: Rancati S 

PROVIDER: S-EPMC12744845 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature