Global burden and epidemiological trends of paediatric-onset multiple sclerosis: a cross-sectional analysis of the 2021 global burden of disease study.

ABSTRACT:

Background

Paediatric-onset Multiple Sclerosis (POMS) is a rare autoimmune disorder of the central nervous system, primarily affecting children and adolescents, characterized by recurrent episodes of neurological impairment. This study delineates the global disease burden and epidemiological characteristics of this condition.

Methods

Data on POMS were obtained from the 2021 Global Burden of Disease (GBD) Study, including estimates from 1990 to 2021. We described the global burden of POMS using incidence, prevalence, DALYs (Disability-Adjusted Life Years), YLDs (Years Lived with Disability), and age-standardized rates. We utilized the Joinpoint Regression Program to analyze the epidemiological trends of POMS disease burden over the past three decades. The Nordpred model was e

SUBMITTER: Zhuo Z 

PROVIDER: S-EPMC12744903 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature