Impact of tumor motion on target delineation and dose calculation accuracy using rapid-acquisition HyperSight CBCT in online adaptive radiotherapy.

ABSTRACT:

Background

HyperSight CBCT offers rapid image acquisition and enhanced image quality, supporting its integration into online adaptive radiotherapy (OART). However, its performance under respiratory-induced tumor motion requires further evaluation.

Purpose

This study evaluates the feasibility of using rapid-acquisition HyperSight CBCT for internal target volume (ITV) delineation and dose calculation in the setting of respiratory motion, with implications for OART workflows.

Methods

A dynamic thoracic phantom simulating superior-inferior tumor motion (5-25 mm amplitude from the motion center, 6-second cycle time) was imaged using Varian's HyperSight CBCT on the Ethos platform. Four reconstruction algorithms were evaluated: filtered back projection (FDK), iterative CBCT

SUBMITTER: Wang YF 

PROVIDER: S-EPMC12744922 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature