Organ-specific equivalent uniform dose constraints and radiobiological parameters for radiation treatment planning of abdominal tumors.

ABSTRACT:

Background

Radiation therapy planning (RTP) for abdominal tumors often requires multiple dose-volume constraints for each organ at risk (OAR), which vary with different fractionation schemes. This variability can complicate biologically optimized treatment planning.

Purpose

This study aims to extract fractionation-independent dose constraints based on the concept of equivalent uniform dose (EUD), utilizing published clinical data for a range of fractionation regimens. The goal is to derive organ-specific radiobiological parameters as well as the EUD for each OAR that can be used in biologically optimized treatment planning for abdominal tumors, independent of the specific fractionation scheme applied.

Methods

Clinical dose-volume constraints for duodenum, stomach, and

SUBMITTER: Dabaghmanesh S 

PROVIDER: S-EPMC12744925 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature