Identification of non-oncology drugs with activity against inflammatory and triple-negative breast cancer cell lines.

ABSTRACT: Inflammatory breast cancer (IBC) and triple-negative breast cancer (TNBC) are subtypes of breast cancer with the lowest 5-year survival rates. One potential approach to increase survival rates for these cancers may be to identify tolerable and inexpensive daily maintenance therapies that could be administered in between standard of care treatments. The present study aimed to identify non-oncology drugs (NODs) that show activity against IBC/TNBC that could be repurposed for this use. Thus, a collection of NODs were screened and curated from a published database using cell line SUM-149, which is both an IBC and TNBC cell line (TN-IBC). In a parallel screening approach, a subset of these NODs were tested for activity against two other TNBC cell lines. Together, 15 drugs with activity against

SUBMITTER: Ahmad S 

PROVIDER: S-EPMC12744928 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature