The Post-Cholecystectomy Gut Microbiota Follows a Time-Varying Change-A Pilot Study.

ABSTRACT:

Background

Gut microbiota is proposed to be a key factor for post-cholecystectomy diarrhea (PCD). Long-term follow-up showed decreasing PCD over time, suggesting microbiota change is time-dependent. Our study aimed to analyze gut microbiota and PCD at different times to clarify their time-varying features.

Methods

Patients aged 20-70 receiving laparoscopic cholecystectomy were recruited prospectively. Subjects with prior abdominal surgery, major systemic diseases, use of antibiotics, probiotics, or proton pump inhibitors within 1 month were excluded. Stool was analyzed at baseline (BL) and 6th, 12th month post-surgery. Microbial diversity was assessed with R phyloseq package, and differential abundance of taxonomic composition with LEfSe/metagenomeSeq.

Results

Ten pat

SUBMITTER: Chiu YT 

PROVIDER: S-EPMC12744953 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature