Virus-Inducible Activation of Hypersensitive Response Confers Broad-Spectrum Resistance to Diverse Viruses in Plants.

ABSTRACT: The hypersensitive response (HR) is a powerful plant defence mechanism that restricts pathogen spread through localised cell death. However, constitutive activation of HR can impair growth and development, limiting its utility in crop breeding and protection. In the study, we developed a virus-inducible HR system by coupling an Avirulence/Resistance (Avr/R) gene pair, Avr4/Cf-4 effector-resistance gene pair, with a promoter (Solyc04g076730) specifically activated by geminivirus infection. We demonstrate that co-expression of Avr4 and Cf-4 in Nicotiana benthamiana triggers robust HR and significantly reduces accumulation of multiple geminiviruses, including TYLCV, TYLCCNV, SLCMV and BSCTV. Transcriptomic analysis of virus-infected tomato identified Solyc04g076730 as a virus-responsive promo

SUBMITTER: Pan RR 

PROVIDER: S-EPMC12744956 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature