Left Ventricular Ejection Fraction and Incident Cardiac Conduction Dysfunction: Exploring the Mediating Effects of Electrophysiological Parameters.

ABSTRACT:

Background

Population-based evidence on the predictive role of left ventricular ejection fraction (LVEF) in incident Cardiac Conduction Dysfunction (CCD) and the mediating effects of electrophysiological parameters remains understudied. This study aimed to characterize the relationship between LVEF and incident CCD and explore the potential mediating effects of electrophysiological parameters.

Methods

This prospective cohort study included 32,398 participants (96.6% White ethnicity) from the UK Biobank with analyzable LVEF and electrocardiogram data. Incident CCD was defined as the first occurrence of atrioventricular block, left bundle branch block, or other conduction disorders. Stepwise backward Cox regression and sensitivity analyses evaluated the association between LVE

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC12744959 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature