Transglutaminase-2 Promotes Microglial Synaptic Phagocytosis and Ameliorates Epileptic Seizures by Inhibiting ABCA1 Ubiquitination.

ABSTRACT:

Background

Epilepsy is a prevalent chronic neurological disorder characterized by its complex pathophysiology, with microglial phagocytosis being crucial for synaptic remodeling and epileptogenesis. Transglutaminase-2 (TGM2) holds a critical role in regulating microglial function and cognitive synaptic plasticity; however, the precise mechanisms by which TGM2 influences synaptic pruning and epileptogenesis remain unclear.

Aim

This study aims to investigate the role of TGM2 in seizure susceptibility and its regulatory effects on microglial-mediated synaptic phagocytosis in a chronic epilepsy model. Accordingly, the following objectives were set: elucidate the fluorescent localization and protein expression characteristics of TGM2 in normal and epileptic brain tissues; analyze

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC12745056 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature