Spinal cord-protective effect of resorcimoline for ischemia-reperfusion injury in a rabbit model.

ABSTRACT:

Objectives

Spinal cord injury can occur after aortic surgery as a result of reactive oxygen species (ROS) generated during ischemia-reperfusion. Resorcimoline is a novel and potent antioxidant that has demonstrated ROS-scavenging activity in vitro. We evaluated the spinal cord-protective effects of resorcimoline and compared its efficacy with that of edaravone, a free-radical scavenger currently used clinically in Japan.

Methods

A spinal cord injury model was established via infrarenal aortic occlusion for 20 minutes in 30 Japanese white rabbits. The animals received saline (control), resorcimoline (6 mg/kg), or edaravone (6 mg/kg) immediately after reperfusion. Neurologic function was assessed using the modified Tarlov score, and a linear mixed model was used to analyze the

SUBMITTER: Kawahara Y 

PROVIDER: S-EPMC12745140 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature