ΔR1_blood, a surrogate of blood-pool gadolinium concentration, is related to body mass index, gender, left ventricular end-diastolic volume index, cardiac index, and field strength at cardiac magnetic resonance late enhancement imaging.

ABSTRACT:

Background

Late gadolinium enhancement imaging is the cornerstone of tissue characterization via cardiac magnetic resonance imaging. The contrast-enhancing effect of gadolinium is caused by a linear increase in tissue longitudinal R1 relaxation rates (R1 = 1/T1). The change in R1 of blood pre- and post-contrast (ΔR1_blood) is therefore a surrogate for the blood-pool gadolinium concentration, which in turn correlates linearly to the tissue gadolinium concentration. The total volume of distribution for gadolinium is the extracellular volume of the body, which differs with body composition, potentially leading to variations in blood-pool and tissue gadolinium concentrations.

Methods

This study is a hypothesis-generating secondary analysis of a dataset of 1098 patients

SUBMITTER: Doeblin P 

PROVIDER: S-EPMC12745147 | biostudies-literature | 2025 Winter

REPOSITORIES: biostudies-literature