A diet-induced obese and diabetic host phenotype reduces mosquito ZIKV infections and remodels gut metabolism.

ABSTRACT:

Introduction

Arbovirus infections, including dengue, Zika, and chikungunya, constitute significant global health threats. The epidemiology of these diseases is closely tied to the biology and ecology of the mosquito Aedes aegypti, particularly regarding its vector competence-the mosquito's ability to acquire, maintain, and transmit pathogens. While genetic variations among mosquito populations have traditionally received the most attention and are often regarded as the main determinants of vector competence, life history components, including immune history, microbiota composition, and nutritional status, are increasingly recognized as critical modulators of this trait. In this context, the increasing prevalence of diet-induced obesity and diabetes in human hosts-a condition

SUBMITTER: Menezes A 

PROVIDER: S-EPMC12745224 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature