Continuous visual stimulus tracking to quantify eye motility in spinocerebellar ataxia type 3.

ABSTRACT:

Introduction

Spinocerebellar ataxias (SCA) form a group of dominantly inherited neurodegenerative diseases represented by progressive cerebellar ataxia and various other neurological deficits. SCA3 is the most prevalent type globally and represents 28% of the autosomal dominant cerebellar ataxias in The Netherlands. The associated oculomotor disorders, with distance esotropia as its hallmark, cause diplopia and often present early. To gain further insight into this, we examined eye movements made during a continuous visual stimulus tracking task (SONDA; Standardized Oculomotor and Neuro-Ophthalmic Disorder Assessment).

Methods

Thirteen genetically confirmed SCA3 cases underwent SONDA, both monocularly and binocularly. As a reference, we used previously collected data from 36

SUBMITTER: de Boer MJ 

PROVIDER: S-EPMC12745225 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature