N-alkyl urea hydroxamic acids as a new class of peptide deformylase inhibitors with antibacterial activity.

ABSTRACT: Peptide deformylase (PDF) is a prokaryotic metalloenzyme that is essential for bacterial growth and is a new target for the development of antibacterial agents. All previously reported PDF inhibitors with sufficient antibacterial activity share the structural feature of a 2-substituted alkanoyl at the P(1)' site. Using a combination of iterative parallel synthesis and traditional medicinal chemistry, we have identified a new class of PDF inhibitors with N-alkyl urea at the P(1)' site. Compounds with MICs of

SUBMITTER: Hackbarth CJ 

PROVIDER: S-EPMC127453 | biostudies-literature | 2002 Sep

REPOSITORIES: biostudies-literature