Glis3 as a critical regulator of Pit1-lineages and renal functions.

ABSTRACT: The Krüppel-like GLIS3 transcription factor acts as an effector on the sonic hedgehog (Shh) pathway, regulating several biological processes and the development and postnatal function of various tissues. Given the major role of Shh signaling during the differentiation and anterior/posterior patterning of the adenohypophysis (AH) anlage, we investigated the potential role of glis3 during AH development in the zebrafish model. Glis3KD embryos exhibited increased expression of early AH-inductive genes lim3 and nkx2.2a, along with an expansion of pit1-positive precursors. This shift led to an overproduction of lactotropes, somatolactotropes, and thyrotropes, at the expense of somatotropes, corticotropes, and melanotropes. The most striking difference is the hyperprolactinemia observed in glis3

SUBMITTER: Rurale G 

PROVIDER: S-EPMC12745328 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature