Enhanced Expression of IL32 mRNA in Skeletal Muscles in the Context of Head and Neck Carcinomas.

ABSTRACT:

Background

Cancer-related sarcopenia (CRS) is a significant complication of head and neck carcinoma (HNC), characterised by muscle degeneration and poor clinical outcomes. Although various dietary and therapeutic interventions have been explored, most of them remain empirical, and the molecular mechanisms underlying CRS are not yet fully understood.

Methods

Transcription profiles of muscle fragments from 29 HNC patients and 8 control donors were analysed by bulk RNA sequencing (6/29 and 3/8) and/or RT-qPCR (29/29 and 5/8). In parallel, differentiating human myoblasts (AB1190) were subjected to indirect co-culture with two types of effector cells: HNC cells (FaDu) or control epithelial cells (NHEK). The contactless effects of effector cells on target myoblasts were investigat

SUBMITTER: Baiche I 

PROVIDER: S-EPMC12745337 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature