The multifaceted roles and diagnostic-therapeutic potential of LINC01410 in malignant tumors and non-malignant disorders.

ABSTRACT: LINC01410 is a recently identified long non-coding RNA located on chromosome 9 that plays a multifaceted role in human diseases. Its dysregulation is closely associated with tumor initiation, progression, and therapeutic response. LINC01410 promotes oncogenesis by modulating key signaling pathways, such as PTEN/AKT, Notch, ErbB, and NF-κB, interacting with non-coding RNA networks, and influencing the expression of proteins involved in tumor biology. Beyond these roles, it contributes to cancer metabolism by regulating glycolysis, lipid droplet accumulation, and exosome-mediated intercellular communication, thereby shaping the tumor microenvironment and enhancing malignancy. Intriguingly, LINC01410 exhibits opposite expression patterns in non-malignant conditions such as preeclampsia and di

SUBMITTER: Zhong K 

PROVIDER: S-EPMC12745413 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature