The Shenlian Fumai Granule attenuates Ach-CaCl₂-induced atrial fibrillation by regulating atrial electrical and structural remodeling.

ABSTRACT:

Background

Preliminary clinical studies indicate that Shenlian Fumai Granule (SLFM) reduces the incidence of arrhythmias following radiofrequency ablation in patients with atrial fibrillation (AF) and improves clinical symptoms. This study investigates the preventive effects and underlying mechanisms of SLFM on AF, providing robust evidence to support its clinical application.

Methods

The potential therapeutic effects of SLFM on AF were investigated using network pharmacology. Subsequently, High Performance Liquid Chromatography-Mass Spectrometry (HPLC-MS) was employed for further analysis of SLFM, while molecular docking was utilized to validate potential targets. The impact of SLFM on the electrophysiology of rat hearts was examined during Langendorff perfusion through ele

SUBMITTER: Kong Y 

PROVIDER: S-EPMC12745443 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature