Autophagic regulation of CD8⁺ T cell metabolic reprogramming defines acute and latent phases of cytomegalovirus infection <i>in vivo</i>.

ABSTRACT: Understanding the immunoregulatory mechanism during cytomegalovirus (CMV) infection may help to combat CMV reactivation in immunocompromised or immunosuppressed individuals. Here we developed a CMV infection model in immunocompetent Sprague Dawley (SD) rats with Priscott strain and explored the cross-talk between autophagic dynamics and metabolism alterations in CD8⁺ T cells post infection. We previously found that primary CMV infection induced a remarkable increase of CD8⁺ T cells which reached the peak around week 3 and returned to pre-inoculation status since week 6 post viral infection. In this study, our results demonstrated that the autophagic activity of CD8⁺ T cells was augmented at week 3 while decreased at week 6, which was closely associated with

SUBMITTER: Liu H 

PROVIDER: S-EPMC12745450 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature