Single-nucleus RNA-seq reveals no increase in T cells in Alzheimer's disease prefrontal cortex or hippocampus.

ABSTRACT:

Background

Alzheimer's disease (AD) has long been associated with hallmark protein aggregates, yet increasing evidence suggests immune involvement may contribute to its progression. Prior studies have found increased T cell presence in AD brain tissue, raising the possibility of neuroimmune crosstalk.

Methods

We used single-nucleus RNA sequencing data from the Religious Orders Study and Memory and Aging Project (ROSMAP), the largest available postmortem AD cohort, to investigate T cell dynamics in prefrontal cortex (PFC) and hippocampus.

Results

Contrary to prior findings, we observed no significant increase in T cell frequency in individuals with pathologically confirmed AD in either region. We replicated these findings in dorsolateral PFC (DLPFC) using the Seattle A

SUBMITTER: Oxendine JD 

PROVIDER: S-EPMC12745470 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature