Association of serum vitamin D levels with mortality in adults with H-type hypertension: Results from the NHANES database with traditional and machine learning approaches.

ABSTRACT:

Objective

This study aimed to investigate the relationship between serum vitamin D (Vit D) levels and the risk of mortality among adults with H-type hypertension, a subtype of hypertension characterized by elevated homocysteine (Hcy) levels.

Methods

This retrospective analysis utilized NHANES 2001 to 2006 to examine associations of Vit D and Hcy with mortality in hypertensive adults overall (n=5459), followed by targeted analyses in H-type hypertension (n=2276). The primary endpoints of the study were all-cause mortality and cardiovascular disease mortality, with follow-up through 2019. Weighted multivariable Cox models, mediation analyses, restricted cubic splines, and machine-learning validation were conducted.

Results

In the overall hypertensive cohort, H-type hype

SUBMITTER: Chen S 

PROVIDER: S-EPMC12745538 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature