Overexpression of miR-516a-5p Promotes Erosive Oral Lichen Planus: In Vitro Study Based on Bioinformatics Analyses.

ABSTRACT:

Objectives

This study aimed to investigate the differentially expressed microRNAs in erosive oral lichen planus, followed by analyzing how the overexpression of identified miR-516a-5p influences human oral mucosal fibroblasts.

Material and methods

High-throughput sequencing using tissues from patients and healthy individuals identified varying microRNA expression profiles in erosive oral lichen planus tissues. Bioinformatics analysis subsequently revealed the enriched pathways and targeted genes involved. In vitro experiments were performed to confirm the validity of bioinformatic findings.

Results

A total of 82 microRNAs were differentially expressed in erosive oral lichen planus tissues. These microRNAs are mainly linked to T helper cell differentiation that enriche

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12745659 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature