Myeloid-Derived CD38 Mediates Age-Related Endometrial Aging Through NAD⁺ Depletion.

ABSTRACT: Against the backdrop of the global trend toward delayed childbearing, elucidating the mechanisms underlying uterine aging has emerged as a critical biomedical priority for addressing age-related implantation failure. Through unbiased global metabolomic profiling of peri-implantation uteri across different ages in mice, we identified nicotinamide adenine dinucleotide (NAD⁺) depletion as a hallmark metabolic feature of endometrial aging. Single-cell RNA sequencing further revealed an expansion of senescent stromal cell populations, which was accompanied by a decline in NAD⁺ levels. Supplementation with NAD⁺ precursors alleviated age-related stromal senescence and endometrial dysfunction, thereby restoring the uterus' implantation competence. Mechanically, we

SUBMITTER: Hua L 

PROVIDER: S-EPMC12745663 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature