Leaf beetles employ tryptophan to detoxify the chemical defenses of poplar trees.

ABSTRACT: Herbivorous insects have evolved many fascinating adaptations to overcome the chemical defenses of their host plants. This study employed targeted and untargeted metabolomics, coupled with isotope labeling, to shed light on the metabolism of salicinoids-potent antiherbivore phenolic defenses present in the Salicaceae family-in the poplar-specialized leaf beetle, Chrysomela tremulae. C. tremulae was found to produce a range of metabolites from salicortin and utilize the essential amino acid tryptophan and its breakdown products, namely kynurenine, kynurenic acid, and 4-hydroxyquinoline, to form novel conjugates with the salicinoid metabolite saligenin, which are then excreted in the feces of the beetles. Saligenin and its conjugates are not toxic to C. tremulae and simi

SUBMITTER: Peng X 

PROVIDER: S-EPMC12745818 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature