Immunoinformatics-Based Multi-Epitope Vaccine Targeting Helicobacter Pylori.

ABSTRACT:

Background

The rising global incidence of Helicobacter pylori-related diseases, particularly gastric cancer, underscores the urgent need for effective preventive vaccines, motivating the exploration of innovative immunoinformatic strategies to address this public health challenge.

Aims

The aim of this study was to design a multi-epitope subunit vaccine for Helicobacter pylori using an immunoinformatics approach. Specifically, the objectives were to predict potential epitopes from the flagellin B and urease B proteins, integrate the cholera toxin B subunit (CTB) as a mucosal adjuvant, and perform computational validation of the vaccine construct for antigenicity, stability, and interaction with immune receptors.

Methods

This study utilized an immunoinformatics approach

SUBMITTER: Pasha AVK 

PROVIDER: S-EPMC12745834 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature