The 3xTg-AD Mouse Model of Alzheimer's Disease Exhibits Lifelong Reductions in Circulating Choline Despite Adequate Dietary Intake, With Sex-Specific Neuropathological and Behavioral Phenotypes.

ABSTRACT: Alzheimer's disease (AD) is a neurodegenerative disease characterized by amyloid-beta plaques and neurofibrillary tau tangles in the brain, neuroinflammation, and cognitive impairment. The 3xTg-AD mouse is a commonly used model in AD studies. 3xTg-AD males display inconsistent pathology; therefore, most studies utilize females. An understanding of why sexual dimorphism exists in this model is lacking. In humans, low circulating choline levels are associated with elevated AD pathology, while higher choline intake reduces pathology in AD mouse models. Here, we sought to understand if blood choline levels are associated with the sex discrepancies observed in 3xTg-AD mice. Body weight and chow consumption were measured, and blood plasma samples were collected at 3, 6, 9, 12 months of age and a

SUBMITTER: Judd JM 

PROVIDER: S-EPMC12745837 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature