Gastroesophageal Reflux, Sleep-Disordered Breathing, and Outcomes in Patients With Idiopathic Pulmonary Fibrosis.

ABSTRACT:

Background

Gastroesophageal reflux disease (GERD) and obstructive sleep apnea (OSA) may negatively impact idiopathic pulmonary fibrosis (IPF), but data on their concurrent contributions are lacking. We aimed to test the contributions of GERD and sleep-disordered breathing (SDB) to IPF outcomes.

Methods

We performed a cross-sectional, exploratory study on subjects with IPF. Clinically established GERD diagnosis, questionnaires (Nocturnal GERD Symptom Severity and Impact Questionnaire [N-GSSIQ], the NIH Patient-Reported Outcomes Measurement Information System [PROMIS] sleep impairment and fatigue scales, and Short Form-36 [SF-36]), full pulmonary function tests (PFT), six-minute walk test (6MWT), and nocturnal polysomnography (PSG) were obtained.

Results

Among n 

SUBMITTER: Ellis B 

PROVIDER: S-EPMC12745840 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature