Safety evaluation of a fungal beta-glucanase.

ABSTRACT: Pig and poultry feed are often included with beta-glucanase to alleviate the anti-nutritional impacts of beta-glucans found in many cereal grains. Safety studies were conducted on beta-glucanase, including skin and eye irritation, dermal sensitization, a 90-day rat oral subchronic study, and genotoxicity, to evaluate the safety of a beta-glucanase for use as an animal feed additive. Beta-glucanase is produced by fermentation with a fungal (Trichoderma reesei) production strain expressing a wild-type fungal endoglucanase (egl2) gene to overexpress the endoglucanase (referred to as beta-glucanase throughout the paper) enzyme. Beta-glucanase was predicted to be non-irritant (No Category) to the skin or eyes in reconstructed human epidermis tissues (RhE) and reconstructed human c

SUBMITTER: Jondhale D 

PROVIDER: S-EPMC12745948 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature